Senior Scientist – Bioinformatics and Data Scientist for Biocatalysis

AstraZeneca

AstraZeneca, a leading biopharmaceutical company, is dedicated to pioneering the discovery and commercialization of life-changing medications. This role within the Early Chemical Development department supports enzyme discovery and process innovation from early-phase drug development through to production. The team is pivotal to creating sustainable and innovative solutions in biocatalysis.

In this role you can expect to have the responsibilities:

• Lead bioinformatics and molecular modelling for enzyme design.
• Manage enzyme variant data and drive biocatalysis data strategy.
• Collaborate to develop computational results databases and dashboards.
• Design enzyme panels using genome and database mining.
• Develop data analysis pipelines for screening and sequencing data.
• Provide bioinformatics expertise across all stages of drug development.
• Coordinate with partners to integrate new technologies in enzyme design.
• Integrate biocatalytic routes with retrosynthetic software.
• Facilitate technology transfer to external manufacturing partners.
• Contribute to innovation through cross-functional network participation.
• Stay updated with biocatalysis and bioinformatics advancements.

This role comes with the following benefits:

• Flexible employee benefits fund including holiday purchase.
• Pension contributions and Share Save Plans.
• Performance recognition scheme.
• Competitive remuneration package.

This role requires you to have:

• Bachelor’s degree in a relevant field.
• Expertise in protein structure analysis, simulation, and design tools.
• Proficiency in Python and strong programming skills.
• Knowledge of statistical analysis and data science tools.
• Experience with machine learning for protein design.
• Ability to work on Linux-based HPC systems.
• Excellent communication skills.

You would benefit from having:

• PhD in computational structural biology or a related field.
• Experience in enzyme panel design.
• Understanding of biochemistry, biocatalysis, and molecular biology.
• Experience with NGS sequence data analysis.
• Knowledge of SQL for database management.

AstraZeneca offers accommodation for individuals with disabilities to participate in the job process and perform essential functions.